Mac Peterson scored a career-high 21 points for San Jose State (8-7, 1-2), going 7-for-12 from behind the arc. Peterson's seven 3-pointers tied a school record.
Chris Oakes added 12 points and a game-high 13 rebounds for the Spartans, who forced just five Bulldogs turnovers.
After trailing 38-29 at halftime, San Jose State battled back in the second half and pulled within 56-54 on an Adrian Oliver layup with 8:48 remaining.
But the Bulldogs responded with a 14-6 scoring run that began when Greg Smith powered past Oakes and converted his own missed layup.
George then went to work, hitting a layup, a fall-away jumper and two 3-pointers in a span of 3 minutes, 18 seconds. Seay capped the surge with a drive to put Fresno State ahead 70-60 with 4:03 left.
San Jose State got no closer than eight points the rest of the way.
George's 29 points matched a career high for the sophomore forward. Freshman center Greg Smith added 10 points and eight rebounds for the Bulldogs, and Steve Shepp had a career-best 10 assists. Fresno State limited Oliver to 12 points, eight below his season average and the first time in eight games he was held under 20.
Peterson helped keep San Jose State within striking distance in the first half by hitting five 3-pointers. His fifth 3 brought the Spartans to within 22-21 with 8:20 left in the half.
The Bulldogs responded with an 8-0 run, capped by a Seay 3-pointer that rolled around the rim and in. Fresno State's starting five accounted for 76 of the team's 80 points.