It happened Monday afternoon just north of Visalia on Highway 63 and Avenue 336.
The California Highway Patrol says a woman in her 20's was traveling northbound when she veered off into the southbound lane. She crashed head-on with another car.
Officers say the driver of that car is a woman in her early-20s. She was airlifted to a Fresno hospital with major injuries.
Officers still don't know what caused the woman to veer into the other lane.
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