It happened on Highway 198 in Coalinga Sunday.
Officers with the Coalinga Police Department say the driver of the motorcycle collided with another vehicle.
The motorcycle driver, 46-year-old Edward Ramirez was airlifted to Community Regional Medical Center to be treated for his injuries. His passenger, 46-year-old Carmen Ramirez died at the scene.
The investigation determined the driver of the car was making an illegal u-turn. That person's identity has not been released.