The man's body was found in a room at the Quality Inn on Ashlan on Highway 99 on April 29th.
Police say the victim had at least one gunshot wound.
The suspect in the killing is 21-year-old Robert Garcia, also known as "Rough."
Investigators say he has a tattoo on his face that says "Sammy" and one on his chest that says "Bulldogs."
They are also looking for 26-year-old Dustin Rutledge, 34-year-old Melanie "Dizzie" Heimgartner and 29-year-old Guadalupe "Lupe" Rivera.
All are wanted for questioning in the case.
If you have any information call Fresno Police.