The CHP said the crash happened around 6 p.m. Wednesday near Tranquillity, on the James Road overpass of Highway 180.
Investigators say the driver of a pickup truck was following a tractor towing irrigation equipment.
The pickup went out of control, hit the back of the tractor and the side of a bridge before catching on fire.
Other drivers tried to save the man in the truck but said the flames were too intense.
The man's name has not been released.
