The victim, 58-year-old Edith McFarland, used a wheelchair after losing her leg in another hit-and-run more than 20 years ago.
Action News interviewed McFarland in 2002 for a story when her wheelchair was stolen.
Delaware State Police say it was approximately 6:35 p.m. when McFarland was attempting to cross the southbound lanes of South Market Street (US 13) near the entrance to the Fairview Inn in her wheelchair.
In the process of crossing the roadway, police say McFarland was struck by what is described as a gold truck or SUV that was traveling southbound on South Market Street.
The impact ejected McFarland from her wheelchair into the southbound lanes of South Market Street, where she was then struck by two additional vehicles, police said.
All three striking vehicles fled southbound on US 13. McFarland was pronounced dead at the scene.
The initial striking vehicle, the gold truck or SUV, has damage to the front end and grill of the vehicle.
The Delaware State Police Crash Reconstruction Unit continues to investigate this incident.