The accident happened around 8 a.m. Saturday morning in Lemoore off Highway 41 at Hanford-Armona Road.
The Highway Patrol says a big rig ran into the back of a Chevy truck that was waiting at a red light. The impact caused a chain reaction crash with another pick-up and an SUV.
The big rig sparked a huge fire. Officers say the 46-year-old driver of the Chevy truck could not escape the flames. He died at the scene.
The other three drivers all walked away with minor injuries.