The shooting happened after a short car chase in Central Fresno Saturday afternoon.
The Fresno Police Department is handling the investigation.
Chief Jerry Dyer says the unidentified suspect was driving more than 90 miles an hour on Highway 99 before crashing near the McKinley off ramp.
Dyer says the man then ignored an officer's demand to see his hands.
He says the officer felt threatened and shot the man.
The suspect has serious injuries but is expected to survive.