The team says X-rays on McFadden's leg were negative and he will not return.
Oakland's leading rushing went to the locker room late in the second quarter Sunday. It was unclear how he was injured. McFadden finished with seven carries for 17 yards.
The Raiders drafted McFadden fourth overall out of Arkansas in 2008. He has proven to be one of the NFL's most dangerous running backs the past two seasons when healthy.
But the problem for McFadden and the Raiders has been staying on the field. He missed 19 games in his first four seasons with foot, toe, shoulder, knee and hamstring injuries.