A win puts the 'Dogs in prime position to win at least a share of the Mountain West title.
One match up to keep your eye on Saturday will be a battle at running back.
The college football landscape changes week to week.
And this week, Fresno State will play its biggest game of the year against Nevada on Saturday.
Despite a loss to Boise St. earlier in the year, this game with the Wolf Pack means more to head coach Tim DeRuyter and the 'Dogs because of the title implications this late in the season.
"I know for the media the Boise game was the game of the year and rightfully so. Our guys look at every week as the game of the year that week. And I think when you do that you play much more consistently. You don't have the high highs and the low lows. And I think our guys will do that this week. You know we've addressed it Monday, and really everyday that we're in a different position. It's November and we're challenging for a conference title and that hadn't happened in a while." said DeRuyter.
One key match up coach DeRuyter has been talking about all week is the marquee battle at running back.
Robbie Rouse is Fresno State's all-time leading rusher.
It's been reported that he was chosen over Visalia's Stefphon Jefferson when Pat Hill was still the coach of the 'Dogs.
Jefferson admits to feeling a bit slighted from the decision years ago.
"I mean they chose Robbie Rouse over me so, I just opened up my mind to a lot of different schools and I came here and I fell in love with it so.
Reporter: Do you want to prove them wrong this week? It's you against Robbie?
Jefferson: Definitely yeah we're both battling to be the best back in the nation and I mean we've just got to come our each and every play and work hard so it'll be fun to watch." added Jefferson.
That decision has perhaps fueled Jefferson into becoming one of the best backs in the country.
The El-Diamante grad is second in the nation in rushing.
But his counterpart, Robbie Rouse is the one with a chance at a title.
The senior has never beaten the Wolf Pack and we asked him if he takes these challenges personally.
"You know I always whenever you get a chance to watch them, I always like to watch them to see what they can do. See what's different in our running styles and things like that so. It's just like I'm sure they do the same thing. said Rouse.
The Fresno State defense is ranked in the top third in the nation, giving up just over 21 points per game.
True freshman Todd Hunt made his first start against Hawaii and recorded three tackles a sack and a forced fumble.
He says the 'Dogs are ready to stop Nevada's offense and stop number 25.
"He's a really good running back. But I mean if we get our scheme right, and do everything that coaches are preaching to us. Then I feel like we'll have no problem containing that guy." said Hunt.