Tyler Johnson scored a team-high 18 points. He had previously missed a game with an ankle injury. Wyoming had come into the game 14-1 on the season.
Fresno State improves to (7-9, 1-2 MW) on the season and will host Nevada at home Saturday 7 p.m.
Also: The women's team almost pulled off a road win against Wyoming, but they fell short Wednesday night 78-71.
Ki Ki Moore scores a team high 18 points and Taylor Thompson chips in 15. The 'Dogs (10-6, 2-1 MW) will be on the road again Saturday at Nevada.