The crash happened near Shepherd and Academy just before 11 a.m. Saturday.
The CHP said Christopher and Deanna Kisling of Fresno were in a 1949 Ford when the big rig driver tried to cross Academy in front of them. The Kislings were not wearing seatbelts, and the impact ejected them from their car.
They are both being treated at Community Regional Medical Center. The big rig driver, Justin Mink, was not hurt.