The SUV hit a tree around 6 p.m. at Ashlan and Willow. Fresno and Clovis firefighters responded to the call.
Crews managed to get the driver out quickly, but they had a harder time freeing the passenger. Authorities said her ankle was stuck under the wreckage, and she had severe injuries to the lower half of her body.
Both victims were taken to Community Regional Medical Center, and their conditions have not yet been released.
Police are still investigating what caused the crash.