The incident ended with a pit maneuver on La Paz Road in Laguna Hills.
The trouble unfolded at about 10 p.m. when a patrol unit saw what appeared to be a drug deal outside a hotel in Anaheim.
When officers attempted to investigate, the woman hopped in a U-Haul pickup truck and took off in one direction while a man hopped into another vehicle and fled the opposite way.
Officers followed the woman who was traveling at speeds of up to 100 mph along the 91, 57 and 5 Freeways.
Authorities shattered her windows with bean bag rounds before taking her into custody. The man remains on the loose.