The ban on indoor marijuana grows takes effect in a month. Those who already have legal plants growing indoors will then have 120 days to harvest their pot.
Outdoor marijuana grows were already illegal in Fresno but now indoor cultivation is banned as well.
The city council passed the amendment 6-1 after it heard impassioned pleas from patients who rely on medical marijuana to deal with health issues.
Joan Byrd told the council, "I grow my own. I am 72 years old and I am so ashamed of all you for not having any compassion."
Despite the indoor and outdoor growing bans, a council committee will look at ways to assist those who need marijuana for health reasons.
Councilmember Sal Quintero said, "It's just sad when folks need it for medicinal purposes are not allowed to have it."
Fresno Police Chief Jerry Dyer said the city has four to five months to find middle ground on the issue.
Dyer explained, "We'll be able to come up with some solutions that will still allow them to meet their needs while at the same time keeping our neighborhoods safe because that's what brought us here today. It's people that are abusing the compassionate use act."
Medical marijuana advocate and attorney Brenda Linder was encouraged the council wants to help patients.
She said, "Just the fact they're willing to look at it and find some other options for people is a step in the right direction."
Some medicinal marijuana users who went before council said they can't afford to go to out of town dispensaries to buy pot.