Officers responded to Howard Avenue north of Ashlan Avenue shortly after 4:00 am.
The CHP says 27-year-old David Lopez was northbound on Howard when, for an unknown reason, he drifted across the southbound lane and crashed into a parked trailer carrying a container along the dirt shoulder of the road.
Lopez was pronounced dead at the scene.
Officers are working to determine the cause of the crash. It wasn't immediately clear if drugs or alcohol were factors.
Authorities had closed the roadway while the Fresno County Coroner's Office conducted their investigation. The road has since reopened.
EDITOR'S NOTE: The video above is from a previous broadcast.