The incident occurred at 12:28 p.m. in the 3800 block of Bristol Street, a spokesperson for the Santa Ana Police Department said, adding that no one on the ground was injured.
According to the Federal Aviation Administration, the twin-engine Cessna 414 aircraft declared an emergency before slamming into the parking lot, belonging to a Staples.
All five aboard were killed instantly. Their identities were not immediately released, but fire officials confirmed all were adults.
The plane struck at least one unoccupied vehicle, whose owner was elsewhere shopping at the time.
"Nobody on the ground was injured, so I don't know anything about what this pilot did or what he was thinking, but it could have been much more tragic. This is a Sunday afternoon, and we have people shopping, so the fact that there are no injuries on the ground is a miracle in itself," said Capt. Tony Bommarito, a spokesman for the Orange County Fire Authority.
The crash site is just north of the popular South Coast Plaza shopping mall and a few blocks northwest of John Wayne Airport, which was the pilot's destination, officials said.
The plane is registered to the San Francisco-based real estate company Category III and had left Concord, according to an FAA database.
Witnesses said the engine cut out as it spiraled toward the ground.
"My godson and I heard the noise, and then I looked up, and it was already lowering down. It, like, lost control, and it was twirling, and the more twirl, the more lower it came down and then we heard the bang," shared witness Connie Hernandez.
Bommarito said responding firefighters did not encounter any flames in the wreckage.
Crews were working to clean up spilled fuel at the location. Meanwhile, Bristol was closed between Sunflower Avenue and Callen's Common.
The cause of the incident will be investigated by the National Transportation Safety Board, with the assistance of the FAA.
The Associated Press contributed to this report.