The crash was reported just before 8 a.m. at Harmony Lane.
Officials say both lanes are blocked and have no estimated time for when the road will be cleared.
Oakhurst Area: State Route 49 CLOSED 2.5 miles north of 41, at Harmony Lane; overturned logging truck. All lanes blocked. No Estimated Time of Opening. pic.twitter.com/NtC02GTNQs— Caltrans District 6 (@CaltransDist6) May 5, 2020
It's unclear if anyone was injured.
This is a developing story.