The crash was first reported around 6:15 a.m.
Officers say a driver in a Nissan pick-up truck was traveling northbound in the two-lane section of Highway 41 near Elkhorn Avenue and started passing cars.
The truck driver side-swiped a Chevy Tahoe in the southbound lane, causing the SUV to spin off the highway. The truck then crashed head-on into a Hyundai Veloster behind the Chevy Tahoe, killing the driver.
CHP officials say the driver of the Nissan was pinned inside the truck when it caught fire. They died at the scene.
Four people inside the Chevy Tahoe were expected to be OK. It's unclear if they had any injuries.
Fresno County: State Route 41 between Elkhorn & Harlan Ave CLOSED due to traffic collision. Southbound traffic detoured at Elkhorn, Northbound traffic detoured at Harlan; both using Elm Ave to get around closure. pic.twitter.com/mDiEDSRi4J— Caltrans District 6 (@CaltransDist6) September 16, 2020
Highway 41 was closed in both directions as officers investigated. It has since reopened.
This is a developing story. Stay with Action News for updates.