Click in the Eyewitness News Story Window above to watch Lisa Hernandez's report from south Los Angeles.
Crenshaw Boulevard and Florence Avenue reopened around 5 a.m. Tuesday.
Investigators say the driver of a Chevy Blazer ran a red light and collided with a Honda Odyssey Van carrying a family of eight.
Witnesses say the Blazer was T-boned by the Honda van. The Blazer went airborne, burst into flames and landed on the sidewalk.
Five people, including two adults in the Blazer and three children in the Honda van, were killed in the crash. One of the children, a 12-year-old boy, was ejected from the van on impact and died at the scene.
"It hit it so fast, then that baby just flew out the window. He flew, we seen him, the oldest child, he flew. Me and my mother was just like 'look at this baby,'" said Vaneda Ward, a witness at the scene. "And that car jumped over the van and they, I know they died because they didn't get out, their car blew up."
Two other children riding in the van, ages 7 and 4, died at the hospital. The parents survived the crash.
The body of the driver of the Chevy Blazer and the body of the passenger were burned beyond recognition.
As many as 16 people from other vehicles involved in the chain-reaction crash are hospitalized, some of them critically.
The LAPD is still working to confirm the identities of the five people killed in the crash.