According to CHP, the truck may have suffered from brake failure. The vehicles were spread over approximately 1 mile stretch of northbound Interstate 5 between Fort Tejon and Grapevine. The location is near the Lebec exit.
There have been reports the truck hit about seven vehicles, including a passenger van that overturned. The van may have had as many as 15 people on board.
Several air ambulances are on the scene.
The northbound 5 Freeway was shut down due to the accident. However, as of 3:30 p.m., the northbound I-5 was reopened.
Stay tuned the Eyewitness News 4 p.m. and abc7.com for the latest on this developing story.