Some injuries were reported but the number and severity was not immediately known, said CHP Officer Jacki Parent.
"It is very, very foggy up there," Lopez said from the CHP dispatch center in San Bernardino, south of the pass.
The chain-reaction collision began when two tractor-trailer rigs crashed in northbound lanes near Oak Hills Road, officers said. At least one diesel spill occurred.
Cajon Pass rises to an elevation of more than 4,100 feet in the San Bernardino Mountains about 45 miles east of Los Angeles. It carries Interstate 15 traffic between Southern California cities, Mojave Desert cities and Las Vegas.
A long jam of northbound traffic stalled at the bottom of the southern side of the pass.
Southern California has been enduring a siege of "June gloom" weather, a deep marine layer that pushes inland from the ocean, bringing low clouds, fog and drizzle.
(Copyright 2009 by The Associated Press. All Rights Reserved.)
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