The home invasion happened Wednesday morning in Ivanhoe, near Road 158 and Wisteria Drive.
The Tulare County Sheriff's Department says the two men held up the family of five, including two teens. A neighbor says the victims were tied up during the attack.
They stole a gun, cell phone, and cash, along with more than thirty medical marijuana plants from the backyard before getting away.
County law requires pot plants be kept inside, in part to deter theft.