The 34-year-old is about to star on-screen as the Green Lantern. The Canadian native is married to actress Scarlett Johansson.
"The sexiest thing about Canadians is that there's an inherent ability to be self-deprecating. That has served me well in my career and personal life," Reynolds told People.
It's the 25th anniversary of People's first sexiest man - Mel Gibson. Others given the title include John F. Kennedy Jr., Harrison Ford and Richard Gere. George Clooney, Brad Pitt and Johnny Depp have won it twice.
The Associated Press contributed to this report.