The piece, called "The Judgment," was taken from the hotel Saturday while a curator was distracted by a guest. Authorities said it was stolen between 10:20 p.m. and 10:35 p.m.
When the curator turned back to the display, the Dutch master's lithograph was gone.
"It appears to be that this was not a crime of opportunity," said Los Angeles County Sheriff's Department spokesman Steve Whitmore. "This was something that was thought out and planned."
The artwork is dated circa 1655 and is about 10 by 6 inches.
The lithograph was part of an exhibit at the hotel sponsored by San Francisco's Linearis Institute.
Investigators are hoping surveillance video from the hotel will help them find the thief. They are also asking anyone who spotted anything suspicious to come forward.
If you have any information regarding this theft, you're urged to contact the Los Angeles County Sheriff's Department's Marina del Rey station at (310) 482-6000.
The Associated Press and City News Service contributed to this report.