The crash happened on Flint near Highway 41 in Kings County just before 9 a.m. Saturday morning.
Officers say they attempted to pull over 21-year-old Christopher Brown but he took off.
They say he led officers on a ten-mile chase that reached speeds of 100-miles per hour before crashing into a semi-truck.
Brown and his 16-year-old passenger were ejected from the car. Both were flown to Community Regional Medical Center with serious injuries.
The driver of the semi-truck was not hurt.