Investigators say a pick-up was driving on the bridge over the San Joaquin River when the driver crossed the center line and slammed into a Toyota Corolla.
Two people in the Corolla suffered major injuries. The driver of the truck was also taken to the hospital. One man was fishing on the bridge when the crash happened.
Art Caballero, witness said, "It was so close and so loud I thought I was going to get hit by one of the vehicles. I threw everything down and ran over and tried to help anybody I could."
The road was shut down for a few hours after the crash. Authorities are still investigating the cause.