The incident happened on the southbound side of the 405 Freeway near Skirball Center Drive at about 1 a.m.
Authorities said a car had hit the center divider when another vehicle plowed into it.
Two people had to be extricated from the car. Three people were riding in the other vehicle.
No major injuries were reported.
Southbound lanes of the freeway were closed for about 15 minutes.