It happened around 11 p.m. Friday night on Ashlan near Highway 41.
Officers say they were trying to pull the man over for high-speed reckless driving when he crashed into a fence and a tree.
The man was pinned in his vehicle, so rescue crews had to use the jaws of life to get him out.
An ambulance took the driver to Community Regional Medical Center with major injuries.
The CHP says it is still investigating if he was under the influence.