Demonstrators held signs in front of the state building Tuesday afternoon.
They say the budget proposal released last week called for $2.5 billion in cuts to health and human services.
Health and social service advocates from organizations including Clinica Sierra Vista, a community health center, said they are calling on legislators to support programs that are vital to a large portion of the community.
"We take care of more than 135,000 people between Inyo, Fresno and Kern counties who don't quite often have insurance, who need services that are paid for through the state budget system. People who will lose those services and potentially their homes should those services be cut," Kevin Hamilton of Clinica Sierra Vista said.
The rally was part of a four-city rally across California with other events taking place in Los Angeles, San Bernardino and San Francisco.