It happened just after 7:30 Wednesday night in an alleyway on West Main near H Street.
Investigators say the 32-year-old victim received multiple stab wounds.
Witnesses say they saw 20 to 30 males beating, kicking and stabbing the man as he lay defenseless in the alley.
They were not able to give police a description of the suspects.
The victim was rushed to a hospital where he underwent surgery for his wounds. He is expected to survive.