There will be plenty of people participating in the half-marathon and relay for a variety of good reasons.
But there's one person in particular who might top them all.
While most runners like Chris Littlecreek will already be challenged by the 13-mile run, his brother Cameron will have an even tougher road ahead.
"My goal before Sunday was to hit 100 miles training and today we're going to do that," Cameron Littlecreek said.
Cameron and Chris have run about 13 miles everyday for about a month to get ready for the race.
Cameron became wheelchair bound at the age of 13 when a car accident left him with a serious spinal injury. To this day Chris still admires his younger brother's resiliency.
"His lack of fear still [amazes me]," Chris Littlecreek said. "And his motivation. You know since the first year after we, after his accident took him out and we went quad riding. And he comes by doing wheelies in fifth gear and everything. Even like full rev since then nothing scares him. Nothing puts him down. If you tell him he can't do it? He's the first to do it."
On this day the brothers are at Woodward Park in Northeast Fresno preparing for the race.
Cameron admits he hasn't really paid attention to the route but knows conquering the Tuolomne Street overpass will be his toughest test.
The 24-year-old may end up being the only wheelchair-bound participant in Sunday's race.
Action News asked him what he thought about being a role model to others like him.
"At first I was a little embarrassed but I just hope that maybe some people get motivated by it and maybe someone who didn't think they could do it will go and try it next year," Cameron said.
But before next year there's this weekend, and both Chris and Cameron Littlecreek have trained hard together for the race. Naturally they expect nothing less but to finish together.