It happened in the 24-hundred block of East Ashcroft in Northeast Fresno.
Police say they got the call just before 10:30 Sunday night.
They found the body of a 25-year-old man inside the home.
Police say he died from a gunshot wound to his upper body.
They say this isn't a random act and the death may be drug and gang-related.
This marks the 43-d murder in Fresno this year.