The crash happened near State Route 43 and Davis Avenue in Fresno County.
One of the vehicles, a blue pickup truck flipped upside down, and then hit and broke a power pole in half. The California Highway Patrol said one person is confirmed dead and two others are severely injured.
CHP said at least 5 additional victims may have injuries but they are still putting together exactly what happened.
HWY 43 is closed just outside of Selma.
