It happened just after 9 a.m. on Highway 41, just north of Mount Whitney Avenue. The California Highway patrol officers say the driver of the pickup truck was traveling north on HWY 41, when he ended up drifting into the south bound lanes.
The impact of that crash killed the driver of the pickup truck immediately. Authorities have not identified the driver of the pickup, or the big rig.
Sgt. Larry Gale of CHP said, "Most of the witnesses I spoke to just saw a big collision, and confirmed the pick-up went onto the path of the big rig on the south bound side."
Traffic was shut down in the area for a few hours as crews worked to clear the scene.
It has since been reopened.