Burse's touchdown returns of 61 and 58 yards came in the first half and tied a Fresno State (2-0) record set in 2005 by Clifton Smith.
David Carr, coming off a record-setting performance last week against Rutgers, threw three touchdowns, including one to Burse. Carr's third TD was to Davante Adams who now has caught a touchdown pass in 10 straight games, adding to his school and Mountain West records.
Carr also adds to the Bulldog record book with 71 career touchdown passes, becoming the third Bulldog to surpass 70.
Chris Brown led the Mustangs (1-1) with three touchdowns. He connected with Willie Tucker for a 7-yard touchdown, and then rushed for two more fourth quarter.
The Bulldogs are in Colorado next Saturday, with an 11:00 a.m. Pacific kickoff.
The Associated Press contributed to this report.