The shooting happened near the corner of Schnoor Street and Avenue 16. Officers say the suspect pulled up next to a truck that had two people inside and opened fire.
Two of the people inside the truck were critically injured. The driver was able to drive about a quarter of a mile before he tried to pull off the road, and crashed into a mailbox.
Officers are still looking for suspects, and they are unsure if the crime is gang related.
If you have any information on the shooting you are urged to call Madera police.