Law enforcement vehicles were seen parked along Valleycrest Drive near the home of the rapper, whose real name is Malcolm James McCormick. The coroner's van arrived on scene shortly before 2:30 p.m.
Sometime around 4 p.m., Miller's body was placed into the van.
His family released a statement regarding Miller's death, but did not release details on how he died.
Warner Bros. Records also released a statement, saying in part that Miller was "a hugely gifted and inspiring artist."
Back in May, McCormick was arrested for allegedly driving under the influence following a crash in Studio City.
McCormick and pop star Ariana Grande had broken up earlier that month, with Grande tweeting afterward: "pls take care of yourself."
pls take care of yourself— Ariana Grande (@ArianaGrande) May 17, 2018
McCormick's last tweet was posted on 6:45 p.m. Thursday about his upcoming tour, set to begin in October.
Go get tickets for tour.— Mac (@MacMiller) September 7, 2018
I’m bringing a band.
The show is going to be special every night.
I wish it started tomorrow.
It starts October 27th.https://t.co/RGYZC5DTza
The Associated Press contributed to this report.