It happened just before 3 am Monday on Elm and North in Fresno County.
CHP officers say the big rig driver was pulling into a driveway when a 2010 Mercury ran into the side of his trailer.
Investigators say Caratachea-Valencia was going about 100 miles an hour and couldn't stop in time.
Due to the impact of the crash, the car became lodged beneath the trailer.
Officers believe Caratachea-Valencia may have been drinking.
The coroner's office will perform toxicology tests to confirm if alcohol was a factor.