The crash happened on Chestnut and McKinley Avenues around 6:00 am.
Fresno police say the driver of a Volkswagen Passat ran a red light, hitting a Yukon and a Mazda.
The driver of the Yukon was taken to the hospital. Their condition wasn't immediately known. No one else was hurt.
Officers say the driver of the Volkswagen did not have a license and was cited.