The crash happened just after 10 pm on Sunday on Swift Avenue and 9th Street.
Officers say 32-year-old Alex McGuigle was speeding when he slammed into a parked truck.
McGuigle was found unconscious and later died at a hospital.
"The motorcycle rider was not wearing a helmet at the time of the collision. I don't know if that's a contributing factor, but it's a pretty substantial collision with a parked vehicle," said Fresno Police Lt. Brian Valles.
It's not clear if drugs or alcohol were involved.