Officers say someone went into the roadway and opened fire at the car at Cedar Avenue and Fountain Way around 3:30 a.m.
The bullet went from the passenger side window through the front windshield, officials say. The suspect is still on the loose.
Police have set up a perimeter in the area to search for the suspect. Officers with the SWAT team are also on the scene to help with the search.
No injuries have been reported. A description of the suspect was not released.
Fresno police are asking for the public to stay away from the area as they continue their investigation.
This is a developing story. Stay with Action News for updates.