The crash happened around 8:30 am near Floral Avenue.
Officials say a black minivan tried to cross the highway at the two-way intersection at Floral Avenue. Officers say the driver didn't see an oncoming truck traveling north on the highway.
The truck driver hit the passengers' side of the van. CHP officials say one person inside the van was killed in the crash. Three other people inside suffered major injuries and were taken to Community Regional Medical Center in Fresno for treatment.
No one in the truck was hurt in the crash.
The northbound lanes of Highway 41 were temporarily closed while crews worked to investigate and clear the crash.
Northbound SR41 at Floral Ave. Major injury crash blocking lanes. Slow down turn headlights on in the fog!!! Expect delays. pic.twitter.com/uJAlMOqYyX— CHP Fresno (@ChpFresno) January 21, 2022