The assault happened Monday night in a parking lot at as fans were heading back to their cars following the game.
The Santa Clara Police Department says officers were dispatched to the incident and upon arrival, the officers learned that all parties involved in the incident had dispersed.
A video of the assault surfaced Tuesday morning on social media and police say detectives were able to identify the four suspects.
On Thursday night, detectives arrested 32-year-old Hollister resident Felix Chavira, 33-year-old Hollister resident Juan Arias, 30-year-old San Jose resident Eric Martinez and an unnamed 17-year-old female.
Since the 49ers moved to Levi's Stadium, Santa Clara police have responded to 24 reports of assault during football games. One case last year involved a man who started a fight in a restroom leaving one of the two victims with a severe brain injury.