It happened at 5:30 am.
Fresno police say the truck was driving eastbound on Kings Canyon Road when the man stepped out into the road. The driver couldn't stop in time and hit him.
The man was taken to a hospital where officers say he later died.
Fresno police have eastbound lanes of Kings Canyon road closed to traffic between Winery and Chestnut Avenues for the investigation. Drivers are advised to avoid the area.