Police were called to Kings Canyon and Argyle for reports of a gunshot victim just before 10:30 on Friday night.
Investigators say a man in his twenties was shot in the lower body.
He was found in an apartment unit. However investigators say he was walking nearby when a man and woman in a car drove up behind him and fired more than 20 rounds.
"It's probably a little more shocking that there were 20+ rounds fired in a residential area. With that many apartment complexes around, unfortunately we did have one victim, however we are also fortunate we didn't have more victims with the number of rounds that were fired," said Fresno Police Lt. Skye Leibee.
Fresno police haven't released a shooter description but say the suspected vehicle involved was a light blue four-door Honda.
Investigators are looking into whether this was gang related and are asking any witnesses to come forward.
The victim was transported to CRMC and is expected to survive.