"Please be kind on me, I'm new at this," said Jenner following a 14-minute long presentation on Jenner's life and career leading up to her gender transformation.
Jenner took the time to speak about the dangers transgender persons face in society, citing the high suicide rate and several recent murders of transgender women in the U.S.
"Trans people deserve something vital," said Jenner. "They deserve your respect."
Amidst tears, Jenner thanked her family for their support, saying she hopes she can make her children proud. Much of Jenner's family was in attendance of the ESPYs, including all of her children.
The award was presented to Jenner by two-time Olympic gold medalist and former 2012 FIFA World Player of the Year Abby Wambach, who recently helped the U.S. win the 2015 FIFA Women's World Cup in Vancouver, Canada.
Wambach and her wife, Sarah Huffman, shared a kiss after the Women's Team's victory against Japan was sealed, a moment that went viral across social media.
The award handoff between the two famed gold medalists, according to an ESPN spokesperson "is significant for the LGBT movement."
Honestly, Caitlyn is an inspiration to so many and that's something you can't deny. #ESPYS— tania (@shotsforzarry) July 16, 2015
"Bruce has received many accolades over the years for being one of the greatest Olympians of our time, but The ESPYS are honored to celebrate Bruce becoming Caitlyn," ESPYs executive producer Maura Mandt said in a press release when it was announced Jenner would receive the Arthur Ashe award. "She has shown the courage to embrace a truth that had been hidden for years, and to embark on a journey that may not only give comfort to those facing similar circumstances, but can also help to educate people on the challenges that the transgender community faces."
PHOTOS: Jenner's changing appearance through the years