LeBron James was ruled out because of an illness and flu-like symptoms and Danny Greenalso missed the game because of a sore right hip, the team announced.
Anthony Davis, who missed Friday's win in Dallas because of a bruised buttocks injury suffered earlier in the week versus New York, was also ruled out.
The Lakers startedRajon Rondo, Avery Bradley, Kentavious Caldwell-Pope, Kyle Kuzma and JaVale McGee.
James, 35, has played in all but one game so far this season for L.A., which the Lakers lost.
LeBron achieves a career first in Lakers' win
LeBron James records 35 points and 16 rebounds in the Lakers' win over the Mavericks -- the first game in James' career in which he had at least 35 points and at least 15 rebounds.