The accident happened at Bradbury Rd. and Clausen Rd. northwest of Delhi just before 4:30 p.m. on Sunday.
The CHP says the teen was riding a Kawasaki motorcycle north on Clausen approaching Bradbury when he ran a stop sign at the intersection.
He was broadsided by a big rig heading east on Bradbury and died at the scene.
The victim is from Turlock, and authorities say he was not wearing a helmet.
The 28-year-old big rig driver was not hurt. He stayed at the scene and is cooperating with the investigation.
Drugs or alcohol are not believed to be factors in the crash.