It happened at around 10 a.m. at the Cherry Market on Cherry Avenue.
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Deputies say the robber pointed a gun at the store clerk demanding money and cigarettes. The man took off with some cash.
Officials say the suspect was driving either an 80s model, two-door GMC JIMMY or a Chevy Trailblazer, with a black stripe painted on the sides. He was last seen heading south on Cherry Avenue and west on Central Avenue.
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If you have any information, you're asked to call the Fresno County Sheriff's Office at 559-600-3111.